Category Archives: Sem categoria


Respiratory syncytial virus fusion protein promotes TLR-4-dependent neutrophil extracellular trap formation by human neutrophils

Plos One
Ano: 2015

Volume: 10
Número: 4

Authors: Funchal GA, Jaeger N, Czepielewski RS, Machado MS, Muraro SP, Stein RT, Bonorino CB, Porto BN

Acute viral bronchiolitis by Respiratory Syncytial Virus (RSV) is the most common respiratory illness in children in the first year of life. RSV bronchiolitis generates large numbers of hospitalizations and an important burden to health systems. Neutrophils and their products are present in the airways of RSV-infected patients who developed increased lung disease. Neutrophil Extracellular Traps (NETs) are formed by the release of granular and nuclear contents of neutrophils in the extracellular space in response to different stimuli and recent studies have proposed a role for NETs in viral infections. In this study, we show that RSV particles and RSV Fusion protein were both capable of inducing NET formation by human neutrophils. Continue reading


Influence of gender and sexual reproductive state in concentration of CAN f 1 in the fur of dogs (Canis lupus familiaris)

World Allergy Organization Journal
Ano: 2015
Volume: 8
Número: 1

Authors: Maicon Paulo, Marconi Rodrigues De Farias, Fábio Nogueira, Michelle Barbosa, L Karla Arruda, Nelson Rosario Filho

The allergens from cats and dogs have been implicated as extrinsic factors involved in sensitization, precipitation and exacerbation of allergic rhinitis and asthma in susceptible children and adults, at rates ranging from 10 to 25%. The major allergen from the epithelium of dogs is the Can f 1, responsible for the majority of sensitivity reactions to these. The Can f 1 is a lipocalin, which confers adhesive properties, derived from the sebaceous glands and found in fur, scales and saliva of dogs. The aim of this study is to assess the influence of gender and sexual reproductive state on concentrations of Can f 1 in the fur of dogs. Continue reading


Fatores de risco para morte por asma

Brazilian Journal of Allergy and Immunology
Ano: 2013
Volume: 1
Número: 3

Autores: Andréia G.O. Fernandes,NP1, Carolina Souza-Machado,MD,PhD1,
Adelmir Souza-Machado,MD,PhD1, Álvaro A. Cruz,MD,PhD1

Objetivo: Revisar a literatura quanto a fatores de risco associados a mortes por asma e estratégias utilizadas para prevenção de óbito entre asmáticos. Métodos: Revisão narrativa a partir dos principais artigos abordando o tema de interesse em português e inglês, publicados nos últimos 30 anos, selecionados nos seguintes bancos de dados: MEDLINE, SciELO, Lilacs e BIREME. Fontes complementares de pesquisa foram os sítios da Organização Mundial de Saúde e do Ministério da Saúde do Brasil. Continue reading